Pan African Journal of Life Sciences(PAJOLS)

A publication of Faculty of Basic Medical Sciences and Faculty of Basic Clinical Sciences,
Ladoke Akintola University of Technology, Ogbomoso

e-ISSN: 2672-5924
Volume 5, No. 3, December 2021
Pages 361-367

DOI: 10.36108/pajols/1202.50.0390

Metabolic Syndrome Associated with Polycystic Ovary Syndrome in Some Nigerian Women

Daniel Adewuni1,2, Titilola A. Samuel2,3, Bolanle Iranloye2,4 Olubunmi Magbagbeola2.3 and Oluyemi Akinloye1,2*
1Department of Medical Laboratory Sciences, Faculty of Basic Medical Sciences, College of Medicine of the University of Lagos
2Centre for Genomics of Non-communicable and Personalized Healthcare, University of Lagos
3Department Department of Biochemistry, Faculty of Basic Medical Sciences, College of Medicine o  the University of Lagos
4Department of Physiology, College of Medicine of the University of Lagos.


Background: Polycystic Ovary Syndrome (PCOS) is a group of symptoms associated with endocrine disorders in women of reproductive age. Women with this syndrome is at increased risk of metabolic syndrome. This study described the metabolic syndrome and its associated components among women with PCOS in Nigerian populace.
Methods: A total of 90 participants (50 PCOS and 40 controls) were recruited for the study. The diagnosis of PCOS was established using the criteria defined by International PCOS guidelines 2018. Demographic, anthropometric, and clinico-pathological data, including blood pressure, were obtained for each participant. Metabolic syndrome was diagnosed using the 2005 revised National Cholesterol Education Program Adult Treatment Panel-III (revised NCEP ATP_III) guidelines. Fasting blood glucose, insulin, total cholesterol, HDL, LDL, and triglycerides were evaluated with conventional spectrophotometric methods.
Results: The prevalence of metabolic syndrome in PCOS women was 24%, with an odds ratio of 5.211, while the prevalence of 5.7% was observed in the control group. The prevalence of central obesity (waist circumference >88cm), FBS ≥100 mg/dl, HDL <50 mg/dl, triglycerides ≥150 mg/dl, and blood pressure ≥130/85 mmHg in PCOS women was 60%, 22%, 54%, 12%, and 20%, respectively. The most frequently observed individual components of metabolic syndrome were increased waist circumference and decreased HDL cholesterol.
Conclusion: Metabolic syndrome and its components, especially obesity, are a major risk factor of PCOS in our population. Routine screening and modulating individual contributors of metabolic syndrome may support PCOS management.

Keywords: Polycystic Ovarian Syndrome, Metabolic Syndrome, Risk Factors

Download PDF